Switch #:
SWTI000117
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S1263 in the BRCT-binding motif of Acetyl-CoA carboxylase 1 (ACACA) induces binding to the Breast cancer type 1 susceptibility protein (BRCA1) protein.

Participants:
(1) Acetyl-CoA carboxylase 1 (ACACA)
(2) Breast cancer type 1 susceptibility protein (BRCA1)

Interactions
Interaction #1 ACACA - BRCA1

Interfaces
(1) LIG_BRCT_BRCA1_1 motif (1262QSPTF1266) in Acetyl-CoA carboxylase 1 (ACACA)
(2) BRCA1 C Terminus (BRCT) domain (1648-1723) and (1756-1842) in Breast cancer type 1 susceptibility protein (BRCA1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S1263 on Acetyl-CoA carboxylase 1 (ACACA)) of the Acetyl-CoA carboxylase 1 (ACACA) LIG_BRCT_BRCA1_1 motif - Breast cancer type 1 susceptibility protein (BRCA1) BRCA1 C Terminus (BRCT) domain interaction

Context
Switch localisation
ELM curated: nucleus, BRCA1-BARD1 complex
References

(1) ACCA phosphopeptide recognition by the BRCT repeats of BRCA1.
Ray et al. J. Mol. Biol. (2006)




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