Switch #:
SWTI000116
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S632 in the 14-3-3-binding motif of Histone deacetylase 4 (HDAC4) induces binding to the 14-3-3 protein beta/alpha (YWHAB) protein. This interaction sequesters Histone deacetylase 4 (HDAC4) in the cytoplasm, thereby inhibiting their transcription repression activity.

Participants:
(1) Histone deacetylase 4 (HDAC4)
(2) 14-3-3 protein beta/alpha (YWHAB)

Interactions
Interaction #1 HDAC4 - YWHAB

Interfaces
(1) LIG_14-3-3_3 motif (629RAQSSP634) in Histone deacetylase 4 (HDAC4)
(2) 14-3-3 protein (5-238) in 14-3-3 protein beta/alpha (YWHAB)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S632 on Histone deacetylase 4 (HDAC4)) of the Histone deacetylase 4 (HDAC4) LIG_14-3-3_3 motif - 14-3-3 protein beta/alpha (YWHAB) 14-3-3 protein interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S632 : Calcium/calmodulin-dependent protein kinase type IV (CAMK4).

Context
Switch localisation
ELM curated: nucleus, cytosol, internal side of plasma membrane
Inferred: transcriptional repressor complex
References

(1) Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization.
Grozinger et al. Proc. Natl. Acad. Sci. U.S.A. (2000)




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