Switch #:
SWTI000112
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S45 by in the 14-3-3-binding motif of Transcription factor p65 (RELA) induces binding to the 14-3-3 protein eta (YWHAH) protein.

Participants:
(1) Transcription factor p65 (RELA)
(2) 14-3-3 protein eta (YWHAH)

Interactions
Interaction #1 RELA - YWHAH

Interfaces
(1) LIG_14-3-3_2 motif (41RSAGSIP47) in Transcription factor p65 (RELA)
(2) 14-3-3 protein (4-241) in 14-3-3 protein eta (YWHAH)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S45 on Transcription factor p65 (RELA)) of the Transcription factor p65 (RELA) LIG_14-3-3_2 motif - 14-3-3 protein eta (YWHAH) 14-3-3 protein interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S45: I-kappa-B kinase subfamily

Context
Switch localisation
ELM curated: cytosol, internal side of plasma membrane, nucleus, mitochondrion


Switch pathways
Inferred: PI3K-Akt signaling pathway
References

(1) Efficient nuclear export of p65-IkappaBalpha complexes requires 14-3-3 proteins.
Aguilera et al. J. Cell. Sci. (2006)




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