Switch #:
SWTI000111
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S197 by in the 14-3-3-binding motif of Forkhead box protein O4 (FOXO4) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein.

Participants:
(1) Forkhead box protein O4 (FOXO4)
(2) 14-3-3 protein zeta/delta (YWHAZ)

Interactions
Interaction #1 FOXO4 - YWHAZ

Interfaces
(1) LIG_14-3-3_2 motif (193RRAASMD199) in Forkhead box protein O4 (FOXO4)
(2) 14-3-3 protein (3-236) in 14-3-3 protein zeta/delta (YWHAZ)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S197 on Forkhead box protein O4 (FOXO4)) of the Forkhead box protein O4 (FOXO4) LIG_14-3-3_2 motif - 14-3-3 protein zeta/delta (YWHAZ) 14-3-3 protein interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S197: RAC-alpha serine/threonine-protein kinase (AKT1)

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S197 : PKB_group, RAC-alpha serine/threonine-protein kinase (AKT1).

Context
Switch localisation
ELM curated: cytosol, internal side of plasma membrane, nucleus, mitochondrion
Inferred: cytosol
References

(1) 14-3-3 Protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4.
Obsilova et al. Biochemistry (2005)




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