Switch #:
SWTI000110
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S392 in the 14-3-3-binding motif of Sodium/calcium exchanger 1 (SLC8A1) induces binding to the 14-3-3 protein epsilon (YWHAE) protein. This interaction inhibits the activity of Sodium/calcium exchanger 1 (SLC8A1).

Participants:
(1) Sodium/calcium exchanger 1 (SLC8A1)
(2) 14-3-3 protein epsilon (YWHAE)

Interactions
Interaction #1 SLC8A1 - YWHAE

Interfaces
(1) LIG_14-3-3_2 motif (388RKAVSMH394) in Sodium/calcium exchanger 1 (SLC8A1)
(2) 14-3-3 protein (4-239) in 14-3-3 protein epsilon (YWHAE)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S392 on Sodium/calcium exchanger 1 (SLC8A1)) of the Sodium/calcium exchanger 1 (SLC8A1) LIG_14-3-3_2 motif - 14-3-3 protein epsilon (YWHAE) 14-3-3 protein interaction

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane
ELM curated: cytosol, internal side of plasma membrane, nucleus, mitochondrion
Inferred: mitochondrion
References

(1) Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins.
Pulina et al. J. Biol. Chem. (2006)




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