Switch #:
SWTI000106
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S257 in the 14-3-3-binding motif of Middle T antigen induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein.

Participants:
(1) Middle T antigen
(2) 14-3-3 protein zeta/delta (YWHAZ)

Interactions
Interaction #1 - YWHAZ

Interfaces
(1) LIG_14-3-3_1 motif (254RSHSYP259) in Middle T antigen
(2) 14-3-3 protein (3-236) in 14-3-3 protein zeta/delta (YWHAZ)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S257 on Middle T antigen) of the Middle T antigen LIG_14-3-3_1 motif - 14-3-3 protein zeta/delta (YWHAZ) 14-3-3 protein interaction

Additional Information
Structural information: 1QJB
Context
Switch localisation
ELM curated: nucleus, cytosol, internal side of plasma membrane
References

(1) The structural basis for 14-3-3:phosphopeptide binding specificity.
Yaffe et al. Cell (1997)




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