Switch #:
SWTI000105
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S137 by RAC-alpha serine/threonine-protein kinase (Akt1) in the 14-3-3-binding motif of Bcl2 antagonist of cell death (Bad) induces binding to the 14-3-3 protein beta/alpha (YWHAB) protein. This interaction inhibits the pro-apoptotic activity of Bcl2 antagonist of cell death (Bad).

Participants:
(1) Bcl2 antagonist of cell death (Bad)
(2) 14-3-3 protein beta/alpha (YWHAB)

Interactions
Context
References

(1) Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11.
Hsu et al. Mol. Endocrinol. (1997)

(2) Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery.
Konishi et al. Mol. Cell (2002)




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