Switch #:
SWTI000104
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S215 in the Pin1-binding motif of Synphilin-1 (SNCAIP) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Synphilin-1 (SNCAIP)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 SNCAIP - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (212PVKSPH217) in Synphilin-1 (SNCAIP)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S215 on Synphilin-1 (SNCAIP)) of the Synphilin-1 (SNCAIP) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Context
References

(1) Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions.
Ryo et al. J. Biol. Chem. (2006)




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