Switch #:
SWTI000093
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T11 in the Pin1-binding motif of Sulfotransferase 4A1 (SULT4A1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Sulfotransferase 4A1 (SULT4A1)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 SULT4A1 - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (8TPSTPG13) in Sulfotransferase 4A1 (SULT4A1)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T11 on Sulfotransferase 4A1 (SULT4A1)) of the Sulfotransferase 4A1 (SULT4A1) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: T11 : Mitogen-activated protein kinase 3 (MAPK3).

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) Cytosolic Aryl sulfotransferase 4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1.
Mitchell et al. Mol. Pharmacol. (2009)

(2) Phosphorylation/dephosphorylation of human SULT4A1: role of Erk1 and PP2A.
Mitchell et al. Biochim. Biophys. Acta (2011)




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