Switch #:
SWTI000078
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S52 in the Pin1-binding motif of Homeobox protein NANOG (Nanog) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein.

Participants:
(1) Homeobox protein NANOG (Nanog)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interactions
Interaction #1 Nanog - Pin1

Interfaces
(1) DOC_WW_Pin1_4 motif (49EAASPR54) in Homeobox protein NANOG (Nanog)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S52 on Homeobox protein NANOG (Nanog)) of the Homeobox protein NANOG (Nanog) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) WW domain interaction

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) Phosphorylation stabilizes Nanog by promoting its interaction with Pin1.
Moretto-Zita et al. Proc. Natl. Acad. Sci. U.S.A. (2010)




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