Switch #:
SWTI000077
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S385 in the Pin1-binding motif of G1/S-specific cyclin-E1 (Ccne1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein.

Participants:
(1) G1/S-specific cyclin-E1 (Ccne1)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interactions
Interaction #1 Ccne1 - Pin1

Interfaces
(1) DOC_WW_Pin1_4 motif (382NRISPP387) in G1/S-specific cyclin-E1 (Ccne1)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S385 on G1/S-specific cyclin-E1 (Ccne1)) of the G1/S-specific cyclin-E1 (Ccne1) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) WW domain interaction

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability.
Yeh et al. J. Biol. Chem. (2006)




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