Switch #:
SWTI000073
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T254 in the Pin1-binding motif of Transcription factor p65 (RELA) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Transcription factor p65 (RELA)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 RELA - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (251VFRTPP256) in Transcription factor p65 (RELA)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T254 on Transcription factor p65 (RELA)) of the Transcription factor p65 (RELA) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Context
References

(1) Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.
Ryo et al. Mol. Cell (2003)




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