Switch #:
SWTI000071
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S213 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Mothers against decapentaplegic homolog 3 (SMAD3)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 SMAD3 - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (210NPMSPA215) in Mothers against decapentaplegic homolog 3 (SMAD3)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S213 on Mothers against decapentaplegic homolog 3 (SMAD3)) of the Mothers against decapentaplegic homolog 3 (SMAD3) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S213 : Cyclin-dependent kinase 2 (CDK2), Cyclin-dependent kinase 2 (Cdk2), Cyclin-dependent kinase 4 (Cdk4), Cyclin-dependent kinase 8 (CDK8), Cyclin-dependent kinase 9 (CDK9), Cyclin-dependent kinase 4 (CDK4), Mitogen-activated protein kinase 1 (MAPK1).

Context
Switch localisation
ELM curated: nucleus, cytosol
Inferred: nucleoplasm
References

(1) Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins.
Nakano et al. J. Biol. Chem. (2009)




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