Description: Phosphorylation of S2136 in the Pin1-binding motif of Neurogenic locus notch homolog protein 1 (NOTCH1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
Participants: (1) Neurogenic locus notch homolog protein 1 (NOTCH1) (2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)
(1) The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer.Rustighi et al. Nat. Cell Biol. (2009)
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