Switch #:
SWTI000058
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S115 in the Pin1-binding motif of Tyrosine-protein kinase BTK (Btk) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein.

Participants:
(1) Tyrosine-protein kinase BTK (Btk)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interactions
Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1.
Yu et al. J. Biol. Chem. (2006)




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