Switch #:
SWTI000052
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S527 in the Pin1-binding motif of Protein PML (PML) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Protein PML (PML)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 PML - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (524GPPSPR529) in Protein PML (PML)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S527 on Protein PML (PML)) of the Protein PML (PML) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Context
References

(1) Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells.
Reineke et al. Mol. Cell. Biol. (2008)




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