Switch #:
SWTI000042
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S528 in the Pin1-binding motif of Transcriptional activator Myb (Myb) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein.

Participants:
(1) Transcriptional activator Myb (Myb)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interactions
Interaction #1 Myb - Pin1

Interfaces
(1) DOC_WW_Pin1_4 motif (525EVESPT530) in Transcriptional activator Myb (Myb)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S528 on Transcriptional activator Myb (Myb)) of the Transcriptional activator Myb (Myb) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) WW domain interaction

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) Pin1 interacts with c-Myb in a phosphorylation-dependent manner and regulates its transactivation activity.
Pani et al. Biochim. Biophys. Acta (2008)




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