Switch #:
SWTI000039
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of T81 in the Pin1-binding motif of Cellular tumor antigen p53 (TP53) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Cellular tumor antigen p53 (TP53)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 TP53 - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (78AAPTPA83) in Cellular tumor antigen p53 (TP53)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T81 on Cellular tumor antigen p53 (TP53)) of the Cellular tumor antigen p53 (TP53) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: T81 : Mitogen-activated protein kinase 8 (MAPK8).

Context
Switch localisation
ELM curated: nucleus, cytosol
Inferred: cytoplasm
References

(1) The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults.
Zacchi et al. Nature (2002)




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