Switch #:
SWTI000036
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of S160 in the Pin1-binding motif of Protein Tax-1 (tax) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.

Participants:
(1) Protein Tax-1 (tax)
(2) Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interactions
Interaction #1 tax - PIN1

Interfaces
(1) DOC_WW_Pin1_4 motif (157YQLSPP162) in Protein Tax-1 (tax)
(2) WW domain (7-37) in Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S160 on Protein Tax-1 (tax)) of the Protein Tax-1 (tax) DOC_WW_Pin1_4 motif - Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) WW domain interaction

Context
Switch localisation
ELM curated: nucleus, cytosol
References

(1) The prolyl isomerase Pin1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein and promotes malignant transformation.
Jeong et al. Biochem. Biophys. Res. Commun. (2009)




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