Description: Hydroxylation of P492 in the VHL-binding motif of Hypoxia-inducible factor 3-alpha (HIF3A) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.
Participants: (1) Hypoxia-inducible factor 3-alpha (HIF3A) (2) Von Hippel-Lindau disease tumor suppressor (VHL)
(1) Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex.Maynard et al. J. Biol. Chem. (2003) (2) Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.Hirsilä et al. J. Biol. Chem. (2003)
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