Switch #:
SWTI000018
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of G1/S-specific cyclin-E1 (CCNE1) at S399 by Cyclin-dependent kinase 2 (CDK2) primes the protein for subsequent phosphorylation at T395 by Glycogen synthase kinase-3 beta (GSK3B).

Participants:
(1) G1/S-specific cyclin-E1 (CCNE1)
(2) Glycogen synthase kinase-3 beta (GSK3B)

Interactions
Interaction #1 CCNE1 - GSK3B

Interfaces
(1) MOD_GSK3_1 motif (392GLLTPPQS399) in G1/S-specific cyclin-E1 (CCNE1)
(2) Protein kinase domain (56-340) in Glycogen synthase kinase-3 beta (GSK3B)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S399 on G1/S-specific cyclin-E1 (CCNE1)) of the G1/S-specific cyclin-E1 (CCNE1) MOD_GSK3_1 motif - Glycogen synthase kinase-3 beta (GSK3B) Protein kinase domain interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S399: Cyclin-dependent kinase 2 (CDK2)

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: S399 : Cyclin-dependent kinase 2 (CDK2).

Context
Switch localisation
ELM curated: cytosol, nucleus
Inferred: centrosome, cytosol


Switch pathways
Inferred: PI3K-Akt signaling pathway, Cell cycle
References

(1) Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.
Welcker et al. Mol. Cell (2003)




Loading visualisation

↑