Description: Phosphorylation of S50 in the PLK-docking motif of M-phase inducer phosphatase 2 (CDC25B) by Cyclin-dependent kinase 1 (CDK1)-Cyclin AB subfamily generates a recruitment site for Serine/threonine-protein kinase PLK1 (PLK1), which then phosphorylates and activates M-phase inducer phosphatase 2 (CDC25B).
Participants: (1) M-phase inducer phosphatase 2 (CDC25B) (2) Serine/threonine-protein kinase PLK1 (PLK1)
(1) Study of the docking-dependent PLK1 phosphorylation of the CDC25B phosphatase.Lobjois et al. Biochem. Biophys. Res. Commun. (2011)
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