PP2A-B56
binding motifs
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PP2A docking motif instances

Gene Protein Sequence Type Start End Species Reference
AIM1Absent in melanoma 1 proteinHFAMPPIHEDHLB56732737Homo sapiens1
ARHGEF2Rho guanine nucleotide exchange factor 2FTRMQDIPEETEB56967972Homo sapiens1
AXIN1Axin-1SGYLPTLNEDEEB56238243Homo sapiens1
BRCA2Breast cancer type 2 susceptibility proteinITELSTILEESGB5611141119Homo sapiens1
BUB1BMitotic checkpoint serine/threonine-protein kinase BUB1 betaIKKLSPIIEDSRB56669674Homo sapiens1,2,3,4,5,6
CCNG1Cyclin-G1ITHLPTIPEMVPB56287292Homo sapiens1
CDCA2Cell division cycle-associated protein 2KPLLSPIPELPEB56590595Homo sapiens1,5,7
CHEK2Serine/threonine-protein kinase Chk2TQELYSIPEDQEB567176Homo sapiens1
EMI2F-box only protein 43 (FBXO43)SRRLSTLREQSSB56384389Homo sapiens1
ESPL1SeparinPEIMRTIPEEELB5614851490Homo sapiens1
FOXO3Forkhead box protein O3QSPMQTIQENKPB56448453Homo sapiens1
KCNH8Potassium voltage-gated channel subfamily H member 8NKRLPSIVEDEEB56706711Homo sapiens1
KIF4AChromosome-associated kinesin KIF4AFSGCSPIEEEAHB5612241229Homo sapiens1
NHSNance-Horan syndrome proteinNTPMQAISEGETB5616261631Homo sapiens1
RACGAP1Rac GTPase-activating protein 1NKRLSTIDESGSB56143148Homo sapiens1,6
MAD3Spindle assembly checkpoint component MAD3PRQLTPILEMREB56477482Saccharomyces cerevisiae1
IntegraseGag-Pro-Pol polyproteinSPRLQPIPETRSB5613781383Human T-cell leukemia virus 1 1
NPNucleoproteinPRMLTPINEEADB56562567Zaire ebolavirus1,8
TJP1Tight junction protein ZO-1DKTLYRIPEPQKB5613231328Homo sapiens6
SYT16Synaptotagmin-16PHVLSSIAEEEHB56137142Homo sapiens6
DENND2CDENN domain-containing protein 2CIQYLETIPESEPB56900905Homo sapiens6
C3orf67Uncharacterized protein C3orf67GERLSSIPEASEB56525530Homo sapiens6
ANKHD1Ankyrin repeat and KH domain-containing protein 1YQPLECIVEETEB56775780Homo sapiens6
KIAA1524Protein CIP2ANRKLESVAEEHEB56717722Homo sapiens6
STON1Stonin-1THVLYPIPESSSB56102107Homo sapiens6


References


      (1) "A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase." Hertz EPT, Kruse T, Davey NE, López-Méndez B, Sigurðsson JO, Montoya G, Olsen JV, Nilsson J. Mol. Cell. 2016 08;63 (4):686-695

      (2) "Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments." Suijkerbuijk SJ, Vleugel M, Teixeira A, Kops GJ. Dev. Cell. 2012 Oct;23 (4):745-55

      (3) "Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression." Kruse T, Zhang G, Larsen MS, Lischetti T, Streicher W, Kragh Nielsen T, Bjørn SP, Nilsson J. J. Cell. Sci.. 2013 Mar;126 (Pt 5):1086-92

      (4) "Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization." Wang J, Wang Z, Yu T, Yang H, Virshup DM, Kops GJ, Lee SH, Zhou W, Li X, Xu W, Rao Z. Protein Cell. 2016 07;7 (7):516-26

      (5) "Expanding the PP2A Interactome by Defining a B56-Specific SLiM." Wang X, Bajaj R, Bollen M, Peti W, Page R. Structure. 2016 12;24 (12):2174-2181

      (6) "PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis." Wu CG, Chen H, Guo F, Yadav VK, Mcilwain SJ, Rowse M, Choudhary A, Lin Z, Li Y, Gu T, Zheng A, Xu Q, Lee W, Resch E, Johnson B, Day J, Ge Y, Ong IM, Burkard ME, Ivarsson Y, Xing Y. Cell Discov. 2017 ;3 ():17027

      (7) "Aurora B defines its own chromosomal targeting by opposing the recruitment of the phosphatase scaffold Repo-Man." Qian J, Beullens M, Lesage B, Bollen M. Curr. Biol.. 2013 Jun;23 (12):1136-43

      (8) "The Ebola Virus Nucleoprotein Recruits the Host PP2A-B56 Phosphatase to Activate Transcriptional Support Activity of VP30." Kruse T, Biedenkopf N, Hertz EPT, Dietzel E, Stalmann G, López-Méndez B, Davey NE, Nilsson J, Becker S. Mol. Cell. 2018 01;69 (1):136-145.e6

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