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PP1 KVxF motif instances

List of experimentally validated KVxF/RVxF motif instances curated from the PP1 literature. All instances have been annotated with their publication and stuctural information if available. All data is clickable to access source data.


Figure 1. Sequence logo of the the KVxF/KxVxF motif
A relative binomial sequence logo constructed as log-10 of the binomial probability (probaa = binomial(k,n,p)) where k is the observed residue count at each position for a residue, n is the number of the instances of motifs and p is the backgound frequency of the residue. A positive score denotes that a residues is enriched, a negative score sugests that a residue is depleted, and score of zero suggest that a residue is occurring at the expected frequency.



Protein Gene Species Peptide PDB Ref.
A-kinase anchor protein 1,mitochondrial AKAP1Homo sapiens 153-plsspKGVLFssksa-157 1
A-kinase anchor protein 11 AKAP11Homo sapiens 1194-sehsgKKVQFaeala-1198 2
A-kinase anchor protein 9 AKAP9Homo sapiens 1064-kimveDKVSFenmtv-1068 3
Adenomatous polyposis coli protein APCHomo sapiens 1628-rlqpqKHVSFtpgdd-1632 4
Ankyrin repeat domain-containing protein 42ANKRD42Homo sapiens 23-npcsrKKVHFgsihd-27 5
Apoptosis regulator Bcl-2BCL2Homo sapiens 146-gvnwgRIVAFfefgg-150 6
Apoptosis-stimulating of p53 protein 2 TP53BP2Homo sapiens 920-riahgMRVKFnplal-924 7
Aurora kinase A AURKAHomo sapiens 342-tykriSRVEFtfpdf-346 8
Aurora kinase A AURKAHomo sapiens 161-kfilaLKVLFkaqle-165 8
Aurora kinase B AURKBHomo sapiens 105-hfivaLKVLFksqie-109 9
Bcl-2-like protein 1 BCL2L1Homo sapiens 139-gvnwgRIVAFfsfgg-143 1
Bcl-2-like protein 2 BCL2L2Homo sapiens 95-gpnwgRLVAFfvfga-99 1
Breast cancer type 1 susceptibility protein BRCA1Homo sapiens 897-lkkqsPKVTFeceqk-901 10
Cell division cycle-associated protein 2 CDCA2Homo sapiens 391-nmrkrKRVTFgedls-3955INB 5IOH 11,12
Centromere-associated protein E CENPEHomo sapiens 419-kakrkRRVTWclgki-423 13
Centrosomal protein of 192 kDa CEP192Homo sapiens 948-navawRCFTFskesv-952 14
Double-stranded RNA-binding protein Staufen homolog 1STAU1Homo sapiens 381-kpgdgRKVTFfepgs-385 15
E3 ubiquitin-protein ligase PPP1R11 PPP1R11Homo sapiens 39-krkpeKKVEWtsdtv-43 16
E3 ubiquitin-protein ligase SH3RF2 SH3RF2Homo sapiens 641-iekqvKTVRFqnysp-645 17,18
Eukaryotic translation initiation factor 2 subunit 2 EIF2S2Homo sapiens 129-kkkkkKNVKFpdede-133 19
H(+)/Cl(-) exchange transporter 7CLCN7Homo sapiens 6-manvsKKVSWsgrdr-10 4
Inactive phospholipase C-like protein 1 PLCL1Homo sapiens 92-cggrkKTVSFssmps-96 20
Inositol 1,4,5-trisphosphate receptor type 1 ITPR1Homo sapiens 2632-dkfdnKTVTFeehik-2636 4
Kinesin-like protein KIF18A KIF18AHomo sapiens 612-lverkKVVVWadqta-616 21
Kinetochore scaffold 1 KNL1Homo sapiens 57-nkknsRRVSFadtik-61
Lethal(2) giant larvae proteinl(2)glDrosophila melanogaster 327-ldftsKVIDFfvtfe-331 22
Metabotropic glutamate receptor 1 GRM1Homo sapiens 891-ansngKSVSWsepgg-895 23
Metabotropic glutamate receptor 5 GRM5Homo sapiens 913-sssngKSVTWaqnek-917 23
Metabotropic glutamate receptor 7 GRM7Homo sapiens NA 23
NARVTFAEAAEII peptideSynthetic---nARVTFaeaae4G9J 24
Neurabin-1 Ppp1r9aRattus norvegicus 456-eipanRKIKFscapi-4603HVQ 25,26,27
Neurabin-1 PPP1R9AHomo sapiens 455-eipanRKIKFssapi-459 25
Neurabin-2 Ppp1r9bRattus norvegicus 447-dpapsRKIHFstapi-4513EGG 3EGH 3EGH 26,27
Neurabin-2 Ppp1r9bRattus norvegicus 574-lrntkGRVRFmigre-578 27
Neurabin-2 PPP1R9BHomo sapiens 445-dpapsRKIHFstapi-449 28
Neuronal migration protein doublecortin DcxMus musculus 53-nekkaKKVRFyrngd-57 29
Neurovirulence factor ICP34.5 RL1Human herpesvirus 1 189-tpatpARVRFsphvr-196 30
Non-POU domain-containing octamer-binding protein NONOHomo sapiens 139-lrgkqLRVRFachsa-143 31
Nuclear inhibitor of protein phosphatase 1 NiPp1Drosophila melanogaster 190-qgrrtRNVTFndeei-194 32
Nuclear inhibitor of protein phosphatase 1 PPP1R8Homo sapiens 199-rkrknSRVTFsedde-2033V4Y 33,34
Nuclear receptor corepressor 1 NCOR1Homo sapiens 413-fdaeqRRVKFinmng-417 35
Nucleolar complex protein 2 homolog NOC2LHomo sapiens 589-icsrrQRVSFgvseq-593 36
Nucleolar MIF4G domain-containing protein 1 NOM1Homo sapiens 306-ekrrgKRVRFaedee-310 37
Opsin-3 OPN3Homo sapiens 362-gdrpkKKVTFnsssi-366 4
Phosphoprotein PHuman respiratory syncytial virus A 83-nyqrkPLVSFkedpt-87 38
Phostensin PPP1R18Homo sapiens 538-rhhkqLKISFsetal-542 39
Potassium voltage-gated channel subfamily A member 6 KCNA6Homo sapiens 72-lgdpgRRVRFfdplr-76 4
Potassium voltage-gated channel subfamily KQT member 2 KCNQ2Homo sapiens 20-sgekkLKVGFvgldp-24 40
Proliferation marker protein Ki-67 MKI67Homo sapiens 504-iplkrRRVSFgghlr-5085J28 12,14,41
Protein mel-28mel-28Caenorhabditis elegans1078-qsasrGRIRFradvp-1082 42
Protein phosphatase 1 regulatory inhibitor subunit 16B PPP1R16BHomo sapiens 62-tggrrKKVSFeasva-66 43
Protein phosphatase 1 regulatory subunit 12A PPP1R12AHomo sapiens 34-vkrqkTKVKFddgav-38 44
Protein phosphatase 1 regulatory subunit 12A PPP1R12AGallus gallus 34-vkrkkTKVKFddgav-38 45
Protein phosphatase 1 regulatory subunit 12B PPP1R12BHomo sapiens 52-trrgsPRVRFedgav-56 46
Protein phosphatase 1 regulatory subunit 12C PPP1R12CHomo sapiens 45-gerraRTVRFeraae-49 47
Protein phosphatase 1 regulatory subunit 14D PPP1R14DHomo sapiens 21-genpcKKVHWasgrr-25 48
Protein phosphatase 1 regulatory subunit 15A PPP1R15AHomo sapiens 554-tplkaRKVRFsekvt-5584XPN 49,50
Protein phosphatase 1 regulatory subunit 15BPPP1R15BHomo sapiens 639-thvkrKKVTFleevt-6434V0U 4V0V 4V0W 4V0X 51
Protein phosphatase 1 regulatory subunit 16A PPP1R16AHomo sapiens 65-sqgllKQVLFppsvv-69 52
Protein phosphatase 1 regulatory subunit 1A PPP1R1AHomo sapiens 8-qdnspRKIQFtvpll-12 53
Protein phosphatase 1 regulatory subunit 1B PPP1R1BBos taurus 7-dpkdrKKIQFsvpap-11 54
Protein phosphatase 1 regulatory subunit 1B PPP1R1BHomo sapiens 7-dpkdrKKIQFsvpap-11 55
Protein phosphatase 1 regulatory subunit 1C PPP1R1CHomo sapiens 7-epnspKKIQFavpvf-11 44
Protein phosphatase 1 regulatory subunit 3A PPP1R3AHomo sapiens 62-pssgtRRVSFadsfg-66 56
Protein phosphatase 1 regulatory subunit 3B PPP1R3BHomo sapiens 61-ekkvkKRVSFadnqg-65 57
Protein phosphatase 1 regulatory subunit 3C PPP1R3CHomo sapiens 83-hnqakKRVVFadskg-87 58
Protein phosphatase 1 regulatory subunit 3D PPP1R3DHomo sapiens 101-gcsqkLRVRFadalg-105 59
Protein phosphatase 1 regulatory subunit 3EPPP1R3EHomo sapiens 86-spdtrKRVRFadalg-90 60
Protein phosphatase 1 regulatory subunit 3F PPP1R3FHomo sapiens 35-aavapRRVLFadeal-39 60
Protein phosphatase inhibitor 2PF3D7_0320000Plasmodium falciparum 12-ksvtkKTISWdevti-16 61
Protein phosphatase inhibitor 2 I-2Arabidopsis thaliana 7-tepkrGRVQWdeani-11 62
Protein phosphatase inhibitor 2 PPP1R2Homo sapiens 43-eelskKSQKWdemni-47 63
Protein phosphatase inhibitor 2 Ppp1r2Mus musculus 12-eelskKSQKWdemni-1692O8A 2O8G 63
Protein SCD5 SCD5Saccharomyces cerevisiae 239-aktgdQKVDFdsfas-243 55
Protein SCD5 SCD5Saccharomyces cerevisiae 272-lnfksKKVRFsehit-276 55
Protein SFI1 homolog SFI1Homo sapiens 951-aiapsRKVTFegpll-955 14
Protocadherin-11 Y-linked PCDH11YHomo sapiens 1046-trpsqRRVTFhlpeg-1050 64
RB1-inducible coiled-coil protein 1 RB1CC1Homo sapiens 1586-kfyrvKAVSWnkkv-1590 4
Resistance to glucose repression protein 1 REG1Saccharomyces cerevisiae 464-kptknRHIHFndrve-468 65,66
Retinoblastoma-associated protein RB1Homo sapiens 873-ppkplKKLRFdiegs-8773N5U 67
Ribosomal RNA processing protein 1 homolog B RRP1BHomo sapiens 682-tpsssKKVTFglnrn-686 14,68
Ryanodine receptor 1 RYR1Homo sapiens 786-sfsagVKVRFllggr-790 69
S-adenosylhomocysteine hydrolase-like protein 1 AHCYL1Homo sapiens 40-tkapkKQIQFaddmq-44 70
Secreted RxLR effector peptide protein,putativePITG_04314Phytophthora infestans 137-hannpNKVTFsnkvr-141 71
Segment polarity protein dishevelled homolog DVL-1 DVL1Homo sapiens 485-lrhtvNKITFseqcy-489 72
Serine/threonine-protein kinase LMTK1 AATKHomo sapiens 1230-lerkkKAVSFfddvt-1234 73
Serine/threonine-protein kinase Nek2 NEK2Homo sapiens 382-ssvikKKVHFsgesk-386 74
Serine/threonine-protein phosphatase 1 regulatory subunit 10 Ppp1r10Rattus norvegicus 373-kgrkrKTVTWpeegk-4244MOY 4MP0 75,76
Serine/threonine-protein phosphatase 1 regulatory subunit 10 PPP1R10Homo sapiens 397-kgrkrKSVTWpeegk-401 77
Serine/threonine-protein phosphatase 1 regulatory subunit GAC1GAC1Saccharomyces cerevisiae 69-ctspeKNVRFaielt-73 78
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A ANKRD28Homo sapiens 1008-ytntsKTVSFealpi-1012 79
Short transient receptor potential channel 5 TRPC5Homo sapiens 795-araksKSVSFnlgck-799 4
Solute carrier family 12 member 2 SLC12A2Homo sapiens 139-eakgrFRVNFvdpaa-143 80
Splicing factor,proline- and glutamine-rich SFPQHomo sapiens 362-mrgrqLRVRFathaa-366 81
TaperinTPRNHomo sapiens 576-ssrkkMKISFndksl-580 82
Telomere length regulator protein RIF1 RIF1Saccharomyces cerevisiae 114-vspvtKSVAFsdrie-118 83
Telomere-associated protein RIF1 RIF1Homo sapiens 2202-pvnkvRRVSFadpiy-2206 14,84
Telomere-associated protein RIF1 Rif1Mus musculus 2150-pvnkiRRVSFadpiy-2154 85
Tensin-1TNS1Homo sapiens 298-rfpeyGKVEFvfsyg-302 86
Testis-specific serine kinase substrate TsksMus musculus 51-itkkkKAVSFhgvep-55 87
Transmembrane protein 225Tmem225Mus musculus 224-phtqaRRVTWal-228 88
Tuberin TSC2Homo sapiens 1289-qgqlhRSVSWadsav-1293 14
Tyrosine-protein kinase Fer FERHomo sapiens 601-dlpqeLKIKFlqeak-605 89
U3 small nucleolar ribonucleoprotein protein MPP10 MPHOSPH10Homo sapiens 329-hkeslKRVTFalpdd-333 14
WW domain-binding protein 11 WBP11Homo sapiens 306-ekksgLSVRFadmpg-310 90
WW domain-binding protein 11 WBP11Homo sapiens 217-vqmygRKVGFaldlp-221 90
YLP motif-containing protein 1 YLPM1Homo sapiens 2097-sepgkKRVRWadlee-2111 91
Zinc finger FYVE domain-containing protein 16 ZFYVE16Homo sapiens 868-cskeqKRVWFadgil-872 92
Zinc finger FYVE domain-containing protein 9 ZFYVE9Homo sapiens 826-qpreqRRVWFadgil-830 93



References


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      (48) "GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA." Liu QR, Zhang PW, Lin Z, Li QF, Woods AS, Troncoso J, Uhl GR. Biochem. J.. 2004 Jan;377 (Pt 1):171-81

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      (54) "DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1." Hemmings HC, Greengard P, Tung HY, Cohen P. Nature. ;310 (5977):503-5

      (55) "Protein phosphatase-1 binding to scd5p is important for regulation of actin organization and endocytosis in yeast." Chang JS, Henry K, Wolf BL, Geli M, Lemmon SK. J. Biol. Chem.. 2002 Dec;277 (50):48002-8

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      (58) "Role of protein targeting to glycogen (PTG) in the regulation of protein phosphatase-1 activity." Brady MJ, Printen JA, Mastick CC, Saltiel AR. J. Biol. Chem.. 1997 Aug;272 (32):20198-204

      (59) "PPP1R6, a novel member of the family of glycogen-targetting subunits of protein phosphatase 1." Armstrong CG, Browne GJ, Cohen P, Cohen PT. FEBS Lett.. 1997 Nov;418 (1-2):210-4

      (60) "Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1." Ceulemans H, Vulsteke V, De Maeyer M, Tatchell K, Stalmans W, Bollen M. J. Biol. Chem.. 2002 Dec;277 (49):47331-7

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      (62) "Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit." Templeton GW, Nimick M, Morrice N, Campbell D, Goudreault M, Gingras AC, Takemiya A, Shimazaki K, Moorhead GB. Biochem. J.. 2011 Apr;435 (1):73-83

      (63) "Structural basis for regulation of protein phosphatase 1 by inhibitor-2." Hurley TD, Yang J, Zhang L, Goodwin KD, Zou Q, Cortese M, Dunker AK, DePaoli-Roach AA. J. Biol. Chem.. 2007 Sep;282 (39):28874-83

      (64) "BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain." Yoshida K, Watanabe M, Kato H, Dutta A, Sugano S. FEBS Lett.. 1999 Oct;460 (1):93-8

      (65) "Functional analysis of the yeast Glc7-binding protein Reg1 identifies a protein phosphatase type 1-binding motif as essential for repression of ADH2 expression." Dombek KM, Voronkova V, Raney A, Young ET. Mol. Cell. Biol.. 1999 Sep;19 (9):6029-40

      (66) "PP1 phosphatase-binding motif in Reg1 protein of Saccharomyces cerevisiae is required for interaction with both the PP1 phosphatase Glc7 and the Snf1 protein kinase." Tabba S, Mangat S, McCartney R, Schmidt MC. Cell. Signal.. 2010 Jul;22 (7):1013-21

      (67) "An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein." Hirschi A, Cecchini M, Steinhardt RC, Schamber MR, Dick FA, Rubin SM. Nat. Struct. Mol. Biol.. 2010 Sep;17 (9):1051-7

      (68) "RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits." Chamousset D, De Wever V, Moorhead GB, Chen Y, Boisvert FM, Lamond AI, Trinkle-Mulcahy L. Mol. Biol. Cell. 2010 Dec;21 (23):4212-26

      (69) "Binding of the catalytic subunit of protein phosphatase-1 to the ryanodine-sensitive calcium release channel protein." Zhao S, Brandt NR, Caswell AH, Lee EY. Biochemistry. 1998 Dec;37 (51):18102-9

      (70) "Protein phosphatase-1 is a novel regulator of the interaction between IRBIT and the inositol 1,4,5-trisphosphate receptor." Devogelaere B, Beullens M, Sammels E, Derua R, Waelkens E, van Lint J, Parys JB, Missiaen L, Bollen M, De Smedt H. Biochem. J.. 2007 Oct;407 (2):303-11

      (71) "A Phytophthora infestans RXLR effector targets plant PP1c isoforms that promote late blight disease." Boevink PC, Wang X, McLellan H, He Q, Naqvi S, Armstrong MR, Zhang W, Hein I, Gilroy EM, Tian Z, Birch PR. Nat Commun. 2016 Jan;7 ():10311

      (72) "Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction." Shimizu N, Ishitani S, Sato A, Shibuya H, Ishitani T. Cell Rep. 2014 Sep;8 (5):1391-404

      (73) "Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation." Gagnon KB, England R, Diehl L, Delpire E. Am. J. Physiol., Cell Physiol.. 2007 May;292 (5):C1809-15

      (74) "NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1." Helps NR, Luo X, Barker HM, Cohen PT. Biochem. J.. 2000 Jul;349 (Pt 2):509-18

      (75) "PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation." Kim YM, Watanabe T, Allen PB, Kim YM, Lee SJ, Greengard P, Nairn AC, Kwon YG. J. Biol. Chem.. 2003 Apr;278 (16):13819-28

      (76) "Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code." Choy MS, Hieke M, Kumar GS, Lewis GR, Gonzalez-DeWhitt KR, Kessler RP, Stein BJ, Hessenberger M, Nairn AC, Peti W, Page R. Proc. Natl. Acad. Sci. U.S.A.. 2014 Mar;111 (11):4097-102

      (77) "Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity." Kreivi JP, Trinkle-Mulcahy L, Lyon CE, Morrice NA, Cohen P, Lamond AI. FEBS Lett.. 1997 Dec;420 (1):57-62

      (78) "Characterization of the inhibition of protein phosphatase-1 by DARPP-32 and inhibitor-2." Huang HB, Horiuchi A, Watanabe T, Shih SR, Tsay HJ, Li HC, Greengard P, Nairn AC. J. Biol. Chem.. 1999 Mar;274 (12):7870-8

      (79) "PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K." Kwiek NC, Thacker DF, Datto MB, Megosh HB, Haystead TA. Cell. Signal.. 2006 Oct;18 (10):1769-78

      (80) "Modulation of ion transport by direct targeting of protein phosphatase type 1 to the Na-K-Cl cotransporter." Darman RB, Flemmer A, Forbush B. J. Biol. Chem.. 2001 Sep;276 (37):34359-62

      (81) "Interaction of protein phosphatase type 1 with a splicing factor." Hirano K, Erdödi F, Patton JG, Hartshorne DJ. FEBS Lett.. 1996 Jul;389 (2):191-4

      (82) "Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1α) docking protein." Ferrar T, Chamousset D, De Wever V, Nimick M, Andersen J, Trinkle-Mulcahy L, Moorhead GB. Biol Open. 2012 Feb;1 (2):128-39

      (83) "Rif1 controls DNA replication timing in yeast through the PP1 phosphatase Glc7." Mattarocci S, Shyian M, Lemmens L, Damay P, Altintas DM, Shi T, Bartholomew CR, Thomä NH, Hardy CF, Shore D. Cell Rep. 2014 Apr;7 (1):62-9

      (84) "Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation." Hiraga SI, Ly T, Garzón J, Hořejší Z, Ohkubo YN, Endo A, Obuse C, Boulton SJ, Lamond AI, Donaldson AD. EMBO Rep.. 2017 03;18 (3):403-419

      (85) "Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1)." Sukackaite R, Cornacchia D, Jensen MR, Mas PJ, Blackledge M, Enervald E, Duan G, Auchynnikava T, Köhn M, Hart DJ, Buonomo SBC. Sci Rep. 2017 05;7 (1):2119

      (86) "Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion." Hall EH, Daugherty AE, Choi CK, Horwitz AF, Brautigan DL. J. Biol. Chem.. 2009 Dec;284 (50):34713-22

      (87) "PPP1CC2 can form a kinase/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis." MacLeod G, Shang P, Booth GT, Mastropaolo LA, Manafpoursakha N, Vogl AW, Varmuza S. Reproduction. 2014 Jan;147 (1):1-12

      (88) "TMEM225: a possible protein phosphatase 1γ2 (PP1γ2) regulator localizes to the equatorial segment in mouse spermatozoa." Matsuura M, Yogo K. Mol. Reprod. Dev.. 2015 Feb;82 (2):139-48

      (89) "Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells." Pasder O, Shpungin S, Salem Y, Makovsky A, Vilchick S, Michaeli S, Malovani H, Nir U. Oncogene. 2006 Jul;25 (30):4194-206

      (90) "SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1." Llorian M, Beullens M, Andrés I, Ortiz JM, Bollen M. Biochem. J.. 2004 Feb;378 (Pt 1):229-38

      (91) "The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G." Ulke-Lemée A, Trinkle-Mulcahy L, Chaulk S, Bernstein NK, Morrice N, Glover M, Lamond AI, Moorhead GB. Biochim. Biophys. Acta. 2007 Oct;1774 (10):1339-50

      (92) "Endofin acts as a Smad anchor for receptor activation in BMP signaling." Shi W, Chang C, Nie S, Xie S, Wan M, Cao X. J. Cell. Sci.. 2007 Apr;120 (Pt 7):1216-24

      (93) "PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster." Bennett D, Alphey L. Nat. Genet.. 2002 Aug;31 (4):419-23

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