List of experimentally validated KVxF/RVxF motif instances curated from the PP1 literature. All instances have been annotated with their publication and stuctural information if available. All data is clickable to access source data.
Figure 1. Sequence logo of the the KVxF/KxVxF motif
A relative binomial sequence logo constructed as log-10 of the binomial probability (probaa = binomial(k,n,p)) where k is the observed residue count at each position for a residue, n is the number of the instances of motifs and p is the backgound frequency of the residue. A positive score denotes that a residues is enriched, a negative score sugests that a residue is depleted, and score of zero suggest that a residue is occurring at the expected frequency.
References
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(91) "The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G." Ulke-Lemée A, Trinkle-Mulcahy L, Chaulk S, Bernstein NK, Morrice N, Glover M, Lamond AI, Moorhead GB. Biochim. Biophys. Acta. 2007 Oct;1774 (10):1339-50
(92) "Endofin acts as a Smad anchor for receptor activation in BMP signaling." Shi W, Chang C, Nie S, Xie S, Wan M, Cao X. J. Cell. Sci.. 2007 Apr;120 (Pt 7):1216-24
(93) "PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster." Bennett D, Alphey L. Nat. Genet.. 2002 Aug;31 (4):419-23