APC/C degron instances

References

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(2) "Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex." He J, Chao WC, Zhang Z, Yang J, Cronin N, Barford D. Mol. Cell. 2013 Jun;50 (5):649-60

(3) "The ABBA Motif Binds APC/C Activators and Is Shared by APC/C Substrates and Regulators." Di Fiore B, Davey NE, Hagting A, Izawa D, Mansfeld J, Gibson TJ, Pines J. Dev. Cell. 2015 Feb;32 (3):358-72

(4) "The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis." Diaz-Martinez LA, Tian W, Li B, Warrington R, Jia L, Brautigam CA, Luo X, Yu H. J. Biol. Chem.. 2015 Jan;290 (4):2431-43

(5) "Molecular basis of APC/C regulation by the spindle assembly checkpoint." Alfieri C, Chang L, Zhang Z, Yang J, Maslen S, Skehel M, Barford D. Nature. 2016 Aug; ():

(6) "Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation." Yamaguchi M, VanderLinden R, Weissmann F, Qiao R, Dube P, Brown NG, Haselbach D, Zhang W, Sidhu SS, Peters JM, Stark H, Schulman BA. Mol. Cell. 2016 Aug;63 (4):593-607

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(10) "Unique D box and KEN box sequences limit ubiquitination of Acm1 and promote pseudosubstrate inhibition of the anaphase-promoting complex." Choi E, Dial JM, Jeong DE, Hall MC. J. Biol. Chem.. 2008 Aug;283 (35):23701-10

(11) "Alk1 and Alk2 are two new cell cycle-regulated haspin-like proteins in budding yeast." Nespoli A, Vercillo R, di Nola L, Diani L, Giannattasio M, Plevani P, Muzi-Falconi M. Cell Cycle. 2006 Jul;5 (13):1464-71

(12) "Mutually dependent degradation of Ama1p and Cdc20p terminates APC/C ubiquitin ligase activity at the completion of meiotic development in yeast." Tan GS, Lewandowski R, Mallory MJ, Strich R, Cooper KF. Cell Div. 2013 ;8 (1):9

(13) "Anillin is a substrate of anaphase-promoting complex/cyclosome (APC/C) that controls spatial contractility of myosin during late cytokinesis." Zhao WM, Fang G. J. Biol. Chem.. 2005 Sep;280 (39):33516-24

(14) "APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle." Juang YL, Huang J, Peters JM, McLaughlin ME, Tai CY, Pellman D. Science. 1997 Feb;275 (5304):1311-4

(15) "A novel motif governs APC-dependent degradation of Drosophila ORC1 in vivo." Araki M, Yu H, Asano M. Genes Dev.. 2005 Oct;19 (20):2458-65

(16) "Centromeric cohesion is protected twice at meiosis, by SHUGOSHINs at anaphase I and by PATRONUS at interkinesis." Cromer L, Jolivet S, Horlow C, Chelysheva L, Heyman J, De Jaeger G, Koncz C, De Veylder L, Mercier R. Curr. Biol.. 2013 Nov;23 (21):2090-9

(17) "Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1." Stewart S, Fang G. Cancer Res.. 2005 Oct;65 (19):8730-5

(18) "Regulated degradation of spindle assembly factors by the anaphase-promoting complex." Song L, Rape M. Mol. Cell. 2010 May;38 (3):369-82

(19) "APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction." Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J, Malumbres M, Letai A, Kirschner MW, Sun Y, Wei W. Dev. Cell. 2014 May;29 (4):377-91

(20) "Cyclin is degraded by the ubiquitin pathway." Glotzer M, Murray AW, Kirschner MW. Nature. 1991 Jan;349 (6305):132-8

(21) "Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates." King RW, Glotzer M, Kirschner MW. Mol. Biol. Cell. 1996 Sep;7 (9):1343-57

(22) "Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase." den Elzen N, Pines J. J. Cell Biol.. 2001 Apr;153 (1):121-36

(23) "Temporal and spatial control of cyclin B1 destruction in metaphase." Clute P, Pines J. Nat. Cell Biol.. 1999 Jun;1 (2):82-7

(24) "The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1." Pfleger CM, Kirschner MW. Genes Dev.. 2000 Mar;14 (6):655-65

(25) "Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis." Zur A, Brandeis M. EMBO J.. 2001 Feb;20 (4):792-801

(26) "Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown." Frye JJ, Brown NG, Petzold G, Watson ER, Grace CR, Nourse A, Jarvis MA, Kriwacki RW, Peters JM, Stark H, Schulman BA. Nat. Struct. Mol. Biol.. 2013 Jul;20 (7):827-35

(27) "Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin." Nguyen TB, Manova K, Capodieci P, Lindon C, Bottega S, Wang XY, Refik-Rogers J, Pines J, Wolgemuth DJ, Koff A. J. Biol. Chem.. 2002 Nov;277 (44):41960-9

(28) "The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe." Yamano H, Gannon J, Hunt T. EMBO J.. 1996 Oct;15 (19):5268-79

(29) "Ama1p-activated anaphase-promoting complex regulates the destruction of Cdc20p during meiosis II." Tan GS, Magurno J, Cooper KF. Mol. Biol. Cell. 2011 Feb;22 (3):315-26

(30) "The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae." Shirayama M, Zachariae W, Ciosk R, Nasmyth K. EMBO J.. 1998 Mar;17 (5):1336-49

(31) "The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae." Charles JF, Jaspersen SL, Tinker-Kulberg RL, Hwang L, Szidon A, Morgan DO. Curr. Biol.. 1998 Apr;8 (9):497-507

(32) "CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis." Mailand N, Diffley JF. Cell. 2005 Sep;122 (6):915-26

(33) "Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC." Ayad NG, Rankin S, Murakami M, Jebanathirajah J, Gygi S, Kirschner MW. Cell. 2003 Apr;113 (1):101-13

(34) "APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase." Amador V, Ge S, Santamaría PG, Guardavaccaro D, Pagano M. Mol. Cell. 2007 Aug;27 (3):462-73

(35) "Degradation of p21Cip1 through anaphase-promoting complex/cyclosome and its activator Cdc20 (APC/CCdc20) ubiquitin ligase complex-mediated ubiquitylation is inhibited by cyclin-dependent kinase 2 in cardiomyocytes." Yamada K, Tamamori-Adachi M, Goto I, Iizuka M, Yasukawa T, Aso T, Okazaki T, Kitajima S. J. Biol. Chem.. 2011 Dec;286 (51):44057-66

(36) "The spike of S phase cyclin Cig2 expression at the G1-S border in fission yeast requires both APC and SCF ubiquitin ligases." Yamano H, Kitamura K, Kominami K, Lehmann A, Katayama S, Hunt T, Toda T. Mol. Cell. 2000 Dec;6 (6):1377-87

(37) "Cell cycle-dependent degradation of the Saccharomyces cerevisiae spindle motor Cin8p requires APC(Cdh1) and a bipartite destruction sequence." Hildebrandt ER, Hoyt MA. Mol. Biol. Cell. 2001 Nov;12 (11):3402-16

(38) "The KEN box regulates Clb2 proteolysis in G1 and at the metaphase-to-anaphase transition." Hendrickson C, Meyn MA, Morabito L, Holloway SL. Curr. Biol.. 2001 Nov;11 (22):1781-7

(39) "A process independent of the anaphase-promoting complex contributes to instability of the yeast S phase cyclin Clb5." Sari F, Braus GH, Irniger S. J. Biol. Chem.. 2007 Sep;282 (36):26614-22

(40) "Fission yeast Cut2 required for anaphase has two destruction boxes." Funabiki H, Yamano H, Nagao K, Tanaka H, Yasuda H, Hunt T, Yanagida M. EMBO J.. 1997 Oct;16 (19):5977-87

(41) "Cyclin A degradation employs preferentially used lysines and a cyclin box function other than Cdk1 binding." Ramachandran V, Matzkies M, Dienemann A, Sprenger F. Cell Cycle. 2007 Jan;6 (2):171-81

(42) "The A-type cyclin CYCA2;3 is a key regulator of ploidy levels in Arabidopsis endoreduplication." Imai KK, Ohashi Y, Tsuge T, Yoshizumi T, Matsui M, Oka A, Aoyama T. Plant Cell. 2006 Feb;18 (2):382-96

(43) "Cell cycle -dependent proteolysis in plants. Identification Of the destruction box pathway and metaphase arrest produced by the proteasome inhibitor mg132" Genschik P, Criqui MC, Parmentier Y, Derevier A, Fleck J. Plant Cell. 1998 Dec;10 (12):2063-76

(44) "Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3." Sigrist S, Jacobs H, Stratmann R, Lehner CF. EMBO J.. 1995 Oct;14 (19):4827-38

(45) "Expression of a nondegradable cyclin B1 affects plant development and leads to endomitosis by inhibiting the formation of a phragmoplast." Weingartner M, Criqui MC, Mészáros T, Binarova P, Schmit AC, Helfer A, Derevier A, Erhardt M, Bögre L, Genschik P. Plant Cell. 2004 Mar;16 (3):643-57

(46) "Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex." Ferreira MF, Santocanale C, Drury LS, Diffley JF. Mol. Cell. Biol.. 2000 Jan;20 (1):242-8

(47) "Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability." Horn SR, Thomenius MJ, Johnson ES, Freel CD, Wu JQ, Coloff JL, Yang CS, Tang W, An J, Ilkayeva OR, Rathmell JC, Newgard CB, Kornbluth S. Mol. Biol. Cell. 2011 Apr;22 (8):1207-16

(48) "Regulation of ciliary polarity by the APC/C." Ganner A, Lienkamp S, Schäfer T, Romaker D, Wegierski T, Park TJ, Spreitzer S, Simons M, Gloy J, Kim E, Wallingford JB, Walz G. Proc. Natl. Acad. Sci. U.S.A.. 2009 Oct;106 (42):17799-804

(49) "Constitutive instability of muscle regulatory factor Myf5 is distinct from its mitosis-specific disappearance, which requires a D-box-like motif overlapping the basic domain." Lindon C, Albagli O, Domeyne P, Montarras D, Pinset C. Mol. Cell. Biol.. 2000 Dec;20 (23):8923-32

(50) "Regulation of MBK-2/Dyrk kinase by dynamic cortical anchoring during the oocyte-to-zygote transition." Stitzel ML, Cheng KC, Seydoux G. Curr. Biol.. 2007 Sep;17 (18):1545-54

(51) "HER4 D-box sequences regulate mitotic progression and degradation of the nuclear HER4 cleavage product s80HER4." Strunk KE, Husted C, Miraglia LC, Sandahl M, Rearick WA, Hunter DM, Earp HS, Muraoka-Cook RS. Cancer Res.. 2007 Jul;67 (14):6582-90

(52) "The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory." Li M, Shin YH, Hou L, Huang X, Wei Z, Klann E, Zhang P. Nat. Cell Biol.. 2008 Sep;10 (9):1083-9

(53) "RCS1, a substrate of APC/C, controls the metaphase to anaphase transition." Zhao WM, Coppinger JA, Seki A, Cheng XL, Yates JR, Fang G. Proc. Natl. Acad. Sci. U.S.A.. 2008 Sep;105 (36):13415-20

(54) "Human KIAA1018/FAN1 nuclease is a new mitotic substrate of APC/C(Cdh1)." Lai F, Hu K, Wu Y, Tang J, Sang Y, Cao J, Kang T. Chin J Cancer. 2012 Sep;31 (9):440-8

(55) "Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor." Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK. Genes Dev.. 2006 Sep;20 (17):2410-20

(56) "The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication." Puklowski A, Homsi Y, Keller D, May M, Chauhan S, Kossatz U, Grünwald V, Kubicka S, Pich A, Manns MP, Hoffmann I, Gönczy P, Malek NP. Nat. Cell Biol.. 2011 Aug;13 (8):1004-9

(57) "Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase." Woodbury EL, Morgan DO. Nat. Cell Biol.. 2007 Jan;9 (1):106-12

(58) "FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner." Laoukili J, Alvarez-Fernandez M, Stahl M, Medema RH. Cell Cycle. 2008 Sep;7 (17):2720-6

(59) "Amyloid β-induced FOXRED2 mediates neuronal cell death via inhibition of proteasome activity." Shim S, Lee W, Chung H, Jung YK. Cell. Mol. Life Sci.. 2011 Jun;68 (12):2115-27

(60) "Gas2l3, a novel constriction site-associated protein whose regulation is mediated by the APC/C Cdh1 complex." Pe'er T, Lahmi R, Sharaby Y, Chorni E, Noach M, Vecsler M, Zlotorynski E, Steen H, Steen JA, Tzur A. PLoS ONE. 2013 ;8 (2):e57532

(61) "OSD1 promotes meiotic progression via APC/C inhibition and forms a regulatory network with TDM and CYCA1;2/TAM." Cromer L, Heyman J, Touati S, Harashima H, Araou E, Girard C, Horlow C, Wassmann K, Schnittger A, De Veylder L, Mercier R. PLoS Genet.. 2012 ;8 (7):e1002865

(62) "Geminin, an inhibitor of DNA replication, is degraded during mitosis." McGarry TJ, Kirschner MW. Cell. 1998 Jun;93 (6):1043-53

(63) "APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity." Fu AK, Hung KW, Fu WY, Shen C, Chen Y, Xia J, Lai KO, Ip NY. Nat. Neurosci.. 2011 Feb;14 (2):181-9

(64) "The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition." Lu L, Hu S, Wei R, Qiu X, Lu K, Fu Y, Li H, Xing G, Li D, Peng R, He F, Zhang L. J. Biol. Chem.. 2013 Dec;288 (50):35637-50

(65) "Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression." Gabellini D, Colaluca IN, Vodermaier HC, Biamonti G, Giacca M, Falaschi A, Riva S, Peverali FA. EMBO J.. 2003 Jul;22 (14):3715-24

(66) "D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p." Burton JL, Solomon MJ. Genes Dev.. 2001 Sep;15 (18):2381-95

(67) "Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth." Lasorella A, Stegmüller J, Guardavaccaro D, Liu G, Carro MS, Rothschild G, de la Torre-Ubieta L, Pagano M, Bonni A, Iavarone A. Nature. 2006 Jul;442 (7101):471-4

(68) "Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle." Morgan D, Eley L, Sayer J, Strachan T, Yates LM, Craighead AS, Goodship JA. Hum. Mol. Genet.. 2002 Dec;11 (26):3345-50

(69) "APC/C is an essential regulator of centrosome clustering." Drosopoulos K, Tang C, Chao WC, Linardopoulos S. Nat Commun. 2014 ;5 ():3686

(70) "Co-regulation proteomics reveals substrates and mechanisms of APC/C-dependent degradation." Singh SA, Winter D, Kirchner M, Chauhan R, Ahmed S, Ozlu N, Tzur A, Steen JA, Steen H. EMBO J.. 2014 Feb;33 (4):385-99

(71) "Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint." Burton JL, Solomon MJ. Genes Dev.. 2007 Mar;21 (6):655-67

(72) "Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest." Harley ME, Allan LA, Sanderson HS, Clarke PR. EMBO J.. 2010 Jul;29 (14):2407-20

(73) "The Drosophila MCPH1-B isoform is a substrate of the APCCdh1 E3 ubiquitin ligase complex." Hainline SG, Rickmyre JL, Neitzel LR, Lee LA, Lee E. Biol Open. 2014 ;3 (7):669-76

(74) "A mutual inhibition between APC/C and its substrate Mes1 required for meiotic progression in fission yeast." Kimata Y, Trickey M, Izawa D, Gannon J, Yamamoto M, Yamano H. Dev. Cell. 2008 Mar;14 (3):446-54

(75) "Degradation of MONOCULM 1 by APC/C(TAD1) regulates rice tillering." Xu C, Wang Y, Yu Y, Duan J, Liao Z, Xiong G, Meng X, Liu G, Qian Q, Li J. Nat Commun. 2012 ;3 ():750

(76) "APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box." Hames RS, Wattam SL, Yamano H, Bacchieri R, Fry AM. EMBO J.. 2001 Dec;20 (24):7117-27

(77) "A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation." Yang Y, Kim AH, Yamada T, Wu B, Bilimoria PM, Ikeuchi Y, de la Iglesia N, Shen J, Bonni A. Science. 2009 Oct;326 (5952):575-8

(78) "Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex." Wang Y, Zhan Q. J. Biol. Chem.. 2007 Jun;282 (24):17712-9

(79) "Anaphase promoting complex-dependent degradation of transcriptional repressors Nrm1 and Yhp1 in Saccharomyces cerevisiae." Ostapenko D, Solomon MJ. Mol. Biol. Cell. 2011 Jul;22 (13):2175-84

(80) "An orc1 allele with a mutated APC motif is female sterile with amplification defects." Park SY, Asano M. Cell Cycle. 2012 Aug;11 (15):2828-32

(81) "The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner." Hilioti Z, Chung YS, Mochizuki Y, Hardy CF, Cohen-Fix O. Curr. Biol.. 2001 Sep;11 (17):1347-52

(82) "Drosophila securin destruction involves a D-box and a KEN-box and promotes anaphase in parallel with Cyclin A degradation." Leismann O, Lehner CF. J. Cell. Sci.. 2003 Jun;116 (Pt 12):2453-60

(83) "piRNA-triggered MIWI ubiquitination and removal by APC/C in late spermatogenesis." Zhao S, Gou LT, Zhang M, Zu LD, Hua MM, Hua Y, Shi HJ, Li Y, Li J, Li D, Wang ED, Liu MF. Dev. Cell. 2013 Jan;24 (1):13-25

(84) "Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells." Lindon C, Pines J. J. Cell Biol.. 2004 Jan;164 (2):233-41

(85) "Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis." Zou H, McGarry TJ, Bernal T, Kirschner MW. Science. 1999 Jul;285 (5426):418-22

(86) "Structural analysis of human Cdc20 supports multisite degron recognition by APC/C." Tian W, Li B, Warrington R, Tomchick DR, Yu H, Luo X. Proc. Natl. Acad. Sci. U.S.A.. 2012 Nov;109 (45):18419-24

(87) "Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome." Heyman J, Van den Daele H, De Wit K, Boudolf V, Berckmans B, Verkest A, Alvim Kamei CL, De Jaeger G, Koncz C, De Veylder L. Plant Cell. 2011 Dec;23 (12):4394-410

(88) "Rice ROOT ARCHITECTURE ASSOCIATED1 binds the proteasome subunit RPT4 and is degraded in a D-box and proteasome-dependent manner." Han Y, Cao H, Jiang J, Xu Y, Du J, Wang X, Yuan M, Wang Z, Xu Z, Chong K. Plant Physiol.. 2008 Oct;148 (2):843-55

(89) "RSS1 regulates the cell cycle and maintains meristematic activity under stress conditions in rice." Ogawa D, Abe K, Miyao A, Kojima M, Sakakibara H, Mizutani M, Morita H, Toda Y, Hobo T, Sato Y, Hattori T, Hirochika H, Takeda S. Nat Commun. 2011 ;2 ():278

(90) "Sgo1 recruits PP2A to chromosomes to ensure sister chromatid bi-orientation during mitosis." Eshleman HD, Morgan DO. J. Cell. Sci.. 2014 Nov;127 (22):4974-83

(91) "Multiple anaphase-promoting complex/cyclosome degrons mediate the degradation of human Sgo1." Karamysheva Z, Diaz-Martinez LA, Crow SE, Li B, Yu H. J. Biol. Chem.. 2009 Jan;284 (3):1772-80

(92) "Regulation of nuclear envelope dynamics via APC/C is necessary for the progression of semi-open mitosis in Schizosaccharomyces japonicus." Aoki K, Shiwa Y, Takada H, Yoshikawa H, Niki H. Genes Cells. 2013 Sep;18 (9):733-52

(93) "The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction." Wan Y, Liu X, Kirschner MW. Mol. Cell. 2001 Nov;8 (5):1027-39

(94) "Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase." Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M. Nature. 2004 Mar;428 (6979):190-3

(95) "Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex." Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG. Nature. 2004 Mar;428 (6979):194-8

(96) "Cdc20 mediates D-box-dependent degradation of Sp100." Wang R, Li KM, Zhou CH, Xue JL, Ji CN, Chen JZ. Biochem. Biophys. Res. Commun.. 2011 Dec;415 (4):702-6

(97) "A novel destruction sequence targets the meiotic regulator Spo13 for anaphase-promoting complex-dependent degradation in anaphase I." Sullivan M, Morgan DO. J. Biol. Chem.. 2007 Jul;282 (27):19710-5

(98) "Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint." Mondal G, Ohashi A, Yang L, Rowley M, Couch FJ. Mol. Cell. 2012 Mar;45 (5):680-95

(99) "Identification of anaphase promoting complex substrates in S. cerevisiae." Ostapenko D, Burton JL, Solomon MJ. PLoS ONE. 2012 ;7 (9):e45895

(100) "Anaphase-promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3." Ohoka N, Sakai S, Onozaki K, Nakanishi M, Hayashi H. Biochem. Biophys. Res. Commun.. 2010 Feb;392 (3):289-94

(101) "Degradation of the human mitotic checkpoint kinase Mps1 is cell cycle-regulated by APC-cCdc20 and APC-cCdh1 ubiquitin ligases." Cui Y, Cheng X, Zhang C, Zhang Y, Li S, Wang C, Guadagno TM. J. Biol. Chem.. 2010 Oct;285 (43):32988-98

(102) "Phosphorylation of Mps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosome instability in melanoma." Liu J, Cheng X, Zhang Y, Li S, Cui H, Zhang L, Shi R, Zhao Z, He C, Wang C, Zhao H, Zhang C, Fisk HA, Guadagno TM, Cui Y. Oncogene. 2013 Feb;32 (6):713-23

(103) "Cell cycle-dependent expression of mammalian E2-C regulated by the anaphase-promoting complex/cyclosome." Yamanaka A, Hatakeyama S, Kominami K, Kitagawa M, Matsumoto M, Nakayama K. Mol. Biol. Cell. 2000 Aug;11 (8):2821-31

(104) "Degradation of human RAP80 is cell cycle regulated by Cdc20 and Cdh1 ubiquitin ligases." Cho HJ, Lee EH, Han SH, Chung HJ, Jeong JH, Kwon J, Kim H. Mol. Cancer Res.. 2012 May;10 (5):615-25

(105) "Meiosis-specific destruction of the Ume6p repressor by the Cdc20-directed APC/C." Mallory MJ, Cooper KF, Strich R. Mol. Cell. 2007 Sep;27 (6):951-61

(106) "APC/C(Cdh1)-mediated degradation of the F-box protein NIPA is regulated by its association with Skp1." Klitzing Cv, Huss R, Illert AL, Fröschl A, Wötzel S, Peschel C, Bassermann F, Duyster J. PLoS ONE. 2011 ;6 (12):e28998

(107) "Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex." Sedgwick GG, Hayward DG, Di Fiore B, Pardo M, Yu L, Pines J, Nilsson J. EMBO J.. 2013 Jan;32 (2):303-14

(108) "Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes." Colombo SL, Palacios-Callender M, Frakich N, De Leon J, Schmitt CA, Boorn L, Davis N, Moncada S. Proc. Natl. Acad. Sci. U.S.A.. 2010 Nov;107 (44):18868-73

(109) "APC/Fizzy-Related targets Aurora-A kinase for proteolysis." Castro A, Arlot-Bonnemains Y, Vigneron S, Labbé JC, Prigent C, Lorca T. EMBO Rep.. 2002 May;3 (5):457-62

(110) "Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit." Littlepage LE, Ruderman JV. Genes Dev.. 2002 Sep;16 (17):2274-85

(111) "Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property." Nguyen HG, Chinnappan D, Urano T, Ravid K. Mol. Cell. Biol.. 2005 Jun;25 (12):4977-92

(112) "APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway." Li R, Wan B, Zhou J, Wang Y, Luo T, Gu X, Chen F, Yu L. PLoS ONE. 2012 ;7 (9):e45932

(113) "KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome." Qi W, Yu H. J. Biol. Chem.. 2007 Feb;282 (6):3672-9

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