APC/C degron repository

The cell tightly regulates protein expression and localisation. Aberrent local abundance of a protein can be highly deleterious and consequently numerous systems exist to control protein trafficking and stability. A key facilitator of these controls are the E3 ubiquitin ligases that poly-ubiquitinate substrates, targeting them to the proteasome thereby promoting their degradation. The Anaphase-promoting complex/Cyclosome (APC/C) is one of the best studied E3 ubiquitin ligases and represents an archetype of a motif-centric regulatory system.

"APC/C degrons acts as specific signals to the cell that a given protein should be destroyed in a cell cycle-dependent manner."

The APC/C recognises short peptides in the disordered regions of their substrates - a subclass of short, linear motifs (SLiMs) known as degrons (derived from degradation motif). APC/C degrons acts as specific signals to the cell that a given protein should be destroyed in a cell cycle-dependent manner. The APC/C degron repository provides information about experimentally characterised degrons and a suite of tools to predict novel degrons in a protein or proteomes of interest. The resource is collaboration between the Davey Lab at The Institute Of Cancer Research (ICR) and the Morgan Lab at the University of California, San Francisco (UCSF).